临床肝移植11例报道

LIVER TRANSPLANTATION (REPORT OF 11 CASES)

目的 探讨肝移植治疗终末期肝病的临床疗效。方法 回顾分析原位肝移植 7例及亲体部分肝移植(LRLT) 4例的临床资料 ,其中肝炎肝硬变 5例 ,肝豆状核变性 6例。对乙肝肝硬变者采用拉米呋啶加小剂量抗HBV Ig治疗。结果 1 0例康复出院 ,1例死于MODS。 4例LRLT全部存活。术后并发症 :腹腔出血 2例 ,ARDS 3例 ;4例乙型肝炎肝硬变者术后HBV DNA( - )。 6例肝豆状核变性 ,术后铜氧化酶均正常。结论 肝移植是终末期肝病的有效治疗手段 ,活体供肝是解决我国供肝来源问题又一方向 ,外科技术是减少围手术期并发症的关键。

Objective To investigate the result of liver transplantation for end stage liver disease. Methods A retrospective analysis was made for 7 cases orthotopic liver transplantation(OLT) and 4 cases living related liver transplantation (5 patients with hepatitis B cirrhosis and 6 with Wilsons disease),cirrhosis group was treated with lamivudine plus low dose anti HBV Ig. Results Ten patients were completely recovered discharged(including 4 cases LRLT) and only 1 died of ARDS.The complications after operation were: 2 cases of abdominal hemorrhage,3 cases of acute respiratory distress syndrome; and 4 cases of hepatitis B cirrhosis were HBV DNA(-) after operation.Copperoxidase in all with Wilsons disease became normal. Conclusion Liver transplantation is effective measure for end stage liver disease and living related liver transplantation is suitable for the present medical condition in China.Surgical technique is crucial for reducing perioperative complications.