缺血性脑血管病不同抗凝治疗方法血小板表面及血浆内GMP-140和IL-6结果比较

A Comparison between GMP-140 and IL-6 in Treated Ischemic Cerebrovascular Disease by Different Anticoagulation Methods

目的：测定缺血性脑血管病患者抗凝前后血小板表面ＧＭＰ－１４０分子数、血浆ＧＭＰ－１４０、白介素－６（ＩＬ－６）含量的变化，进而比较不同药物抗凝效果。方法：用放免法测定８０例缺血性脑血管病患者和３０例对照组血小板表面ＧＭＰ－１４０分子数、血浆ＧＭＰ－１４０和ＩＬ－６含量，并按缺血性质，临床脑神经功能缺损程度和不同药物治疗前后分组。结果 脑血栓形成组和短暂性脑缺血发作组血小板表面及血浆ＧＭＰ－１４０和ＩＬ－６含量均明显高于其对照组；抗凝后均明显低于抗凝前并随时间呈下降趋势；抗凝前与抗凝后第三天血小板及血浆ＧＭＰ－１４０含量之间呈正相关（ｒ＝０．５５，ｒ＝０．６５，Ｐ值均＜０．０５）；低分子肝素抗凝稍好于其它方法，联合治疗优于单项治疗（Ｐ＜０．０５）。结论：缺血性脑血管病患者应用联合治疗效果更好。

OBJECTIVE: To check the change of Granule Membrane Protein- 140 (GMP-140) platelet surface molecule's amount,plasma GMP-140,and interleukin (IL-6) in the patient with cranial apoplexy,further more to reflect the effect of using different anticoagulation ways.Method:80 cases of this disease and 30 cases of the control group have been detected by radioimmunoassay(RIA).Results:the contents of platelet surface GMP-140,plasma GMP-140,IL-6 in transient cerebral ischemia attack(TIA)and cerebral thrombosis groups were obviously higher than that in control groups;comparine the platelet surface GMP-140,plasma GMP-140, and IL-6,we found that their contents was obviously lower than that of pretreatment. It has been found that above mater's contents were drop as time went by. The comparison between before anticoagulation and after anticoagulation in the third day on GMP-140 of platelet and plasma was positive relationship(r=0.05,r=0.65, P<0.05).It has effect on the patient when using urokinase and low molecule heparin, but the later is better than the other anticoagulation methods.Conclusion:The theraputic alliance could got the better treatment than the single treatment for the patients with ischemic cerbrovascular diseases.