肺癌患者血清CEA、CA125、胃泌素及NSE临床价值研究

Clinical Value of Serum CEA，CA125，Gastrin and NSE in Patients with Lung Cancer

目的：对肺癌患者进行4项血清学指标测定，探讨其在肺癌诊断、分期及疗效判定等方面的作用。方法：采用免疫放射分析法对肺癌组（51例）、肺良性疾病组（32例）、正常对照组（68例）进行血清癌胚抗原（CEA）、糖类抗原125（CA125）、胃泌素及神经元特异性烯醇化酶（NSE）含量测定。两组均数差别显著性分析采用t检验进行统计学处理。结果：肺癌患者4项指标血清水平显著高于正常对照组和肺良性疾病组（P＜0．001）其增高的程度与肺癌TNM分期具有一定的相关性。血清CEA、CA125、胃泌素、NSE测定诊断肺癌的敏感性分别为72．16％、62．75％、70．58％、49．02％特异性分别为97．00％、99．00％、82．00％、98．00％。结论：结果提示肺癌患者血清CEA、CA125、胃泌素及NSE水平明显增高血清CEA、CA125水平测定对肺腺癌的诊断价值较高；而胃泌素及NSE对小细胞肺癌的诊断意义较大。多项指标的联合检测对于肺癌的诊断、分期及疗效判定具有一定的实用价值。

Objective The levels of serum CEA CA125 Gastrin and NSE were detected and its significance in diagnosis staging and curative effect of lung cancer were evaluated． Methods Content of serum CEA CA125 Gastrin and NSE were detected by radioimmunoassay in lung cancer group 51 cases benign pulmonary diseases 32 cases and normal control 68 cases． The different significance beweeen these groups were analysed by t－Test． Results The serum CEA CA125 Gastrin and NSE levels in lung cancer group were significantly higher than those in normal control group and benign pulmonary diseases group P＜0．001． The degree of increase was directly associated with the lung cancer TNM stage． The sequence of increase showed Stage Ⅳ＞Stage Ⅲ＞Stage Ⅱ． The sensitivity rates of serum CEA CA125 Gastrin and NSE in diagnosing lung cancer were 72．16％ 62．75％ 70．58％ and 49．02％ respectively． The specificity rates were 97％ 99％ 82％ 98％ respectively． Conclusion As the results showed that serum CEA CA125 Gastrin and NSE are high in lung cancer group therefore detection of multi－serological index has important practical value for diagnosis staging and predicting prognosis of lung cancer．