sIL-2R、Te和抗风疹病毒IgG与系统性红斑狼疮的关系

sIL-2、Te和抗风疹病毒IgG与系统性红斑狼疮的关系

选择 5 9例系统性红斑狼疮 ( SL E)住院患者和 2 0例正常人 ,检测白细胞介素 - 2受体 ( s IL- 2 R)、睾酮( Te)和抗风疹病毒 Ig G,用疾病活动评分 ( SL AM)判断疾病活动性。结果 :SL E患者血清 s IL - 2 R及抗风疹病毒Ig G水平显著高于正常人 ( P<0 .0 0 1) ;Te显著低于正常人 ( P<0 .0 0 1)。 SL E活动期 s IL- 2 R、抗风疹病毒 Ig G水平与 SL AM指数显著高于非活动期 ( P<0 .0 1) ;Te显著低于非活动期 ( P<0 .0 1)。Te含量和 s IL- 2 R浓度呈负相关。提示 :Te能使抑制性 T细胞数量和功能恢复 ,s IL - 2 R数增加 ,有利于 SL E患者病情缓解 ;性激素、细胞因子和病毒感染与 SL E的发病有关 ,并与 SL E的活动性密切相关 ,为 SL

To investigate the relationship between the etiology of SLE and cellular factor,sex hormone,virus infection,the soluble interleukin 2 receptor(sIL 2R),testosterone(Te)and IgG type antibody to rubella virus IgG were detected in 59 SLE inpatients and 20 normal persons SLAM was used to determine the activity of the disease The levels of sIL 2R and antibody to rubella virus IgG were increased significantly in patients(P<0 001),the Te level decreased markedly(P<0 001) The first two were also more remarkable in active SLE than that in inactive SLE,so was the SLAM index(P<0 01) The Te level decreased significantly in active SLE(P<0 01),Te content was negatively related to sIL 2R concentration These suggest sIL 2R,Te and antibody to rubella virus IgG in serum are intimately correlated with etiology and activity of SLE The negative relationship of Te and sIL 2R level provides a theoretic basis in the endocrine treatment and prevention of SLE