黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction

目的：探讨黄芪保心汤地实验性急性心肌缺血大鼠血浆内皮素（ＥＴ）、降钙素基因相关肽（ＣＧＲＰ）水平的影响。方法必只大白鼠随机分为４组：假手术组，模型对照组，黄芪保心汤组，复方丹参滴丸组。结扎左冠状动脉前降支造成急性心肌缺血模型，观察３ｈ后，从腹主动脉取血检测血浆ＥＴ、ＣＧＲＰ水平。结果：黄芪保心汤组，能显著降低血浆ＥＴ含量（Ｐ＜０．００１），升高血浆ＧＧＲＰ水平（Ｐ＜０．０１）。结论：以益气活血祛痰化浊为主的黄芪保心汤有调节急性心肌缺血时血浆ＥＴ、ＣＧＲＰ水平失衡的作用，改善心肌缺血、缺氧状态，减少心肌缺血损伤，且作用优于复方丹参滴丸。

OBJECTIVE: To investigate the influence of Astragalus heart keeping decoction on the level of plasma endothelin( El') and calcitonin gene related peptide (CGRP) in rats during the coronary artery occlusion in vivo. METHODS: 44 rats were devided randomly into the sham ligation group, the control group, the Astragalus heart -keeping decoction (AHKD) group, the Composite Danshen Droplet Pills (CDDP) group. Various groups of the rats were fed with water , AHKD , CDDP for four weeks, respectively. And then rats were subjected to left anterior descending artery occlusion for 3 hour. for the determination of plasma El' and CGRP. RESULTS: the level of plasma ET was lower on average in the group of AHKD than in the control group( P <0.01) ,and in comparison with the control group there was no significant difference in plasma ET in the group of CDDP (P <0.05). The level of plasma CGRP in the AHKD and CDDP groups was higher than that of plasma CGRP in the control group (P<0.01). CONCLU. SION : AHKD and CDDP have the function to regulate the level of plasma ET and CGRP in rats during the coronary artery occlusion, to improve myocardial ischemia ,and that the efficacy of AHKD is superior to that of CDDP.