褪黑激素明胶微球剂与溶液剂鼻粘膜给药比较

Comparison of the differences between melatonin gelatin microspheres and solution in nasal delivery system

目的：比较明胶微球剂与溶液剂的鼻粘膜给药。方法：通过鼻粘膜滞留时间及药物鼻粘膜吸收等实验，比较明胶微球及溶液２种给药制剂的区别。结果：明胶微球剂在鼻粘膜滞留时间明显比溶液剂长，能明显提高药物鼻粘膜吸收，并延长药物在体内滞留时间。结论：明胶微球明显提高药物鼻粘膜吸收，具有很好应用前景。

OBJECTIVE: To compare the differences between gelatin microspheres and solution in nasal delivery system. METHODS : The residence time in nasal mucosa and nasal absorption experiments were performed respectively to compare the differences between gelatin microspheres and solution. RESIJLTS: The residence time of gelatin microspheres was longer than gelatin solution in nasal cavity, gelatin microspheres evidently raised melatonin nasal absorption and prolonged the retention time in blood circulation. CONCLUTION: Gelatin microspheres could raise melatonin nasal absorption and would have good application prospects.