甲磺酸甲氟哌酸糖衣片溶出度测定方法考察

Dissolution study of pefloxacin tablets

目的：对甲磺酸甲氟哌酸糖衣片体外溶出度测定方法进行考察，为评定和控制药品内在质量提供依据。右法：采用紫外法对甲磺酸甲氟哌酸糖衣片溶出度进行测定，并对转篮法和浆法两种测定方法进行了比较。结果：两种测定方法的溶出参数 Ｔ５０、Ｔｄ、ｍ经成组比较ｔ检验，差异显著（Ｐ＜０．０１）。结论：使用转篮法测甲磺酸甲氟哌酸糖衣片效果较好。

OBJECTIVE: To study the dissolution of pefloxacin tables. METHODS: The dissolution rate of pefloxacin tablets was determined by ultraviolet spectrophotometry. At the same time, rotating basket method and oaring method ware compared. RESULTS: There was signifficant difference (P <0. 01) in T50 and Td between rotating basket method and oaring method. CONCLUSION: Using rotating basket method to test dissolution is better than using oaring method.