6-氟-7-氯-1,4-二氢-4-氧代喹啉-3-羧酸乙酯及其类似物的合成

Synthesis of 6-Floro-7-Chloro-1,4-Dihydro 4-Oxoquinoline-3-Carboxlic Acid Ethyl Ester and Anologys

采用微波辐射方法替代传统加热方法 ,由 3-氯 -4 -氟苯胺与乙氧甲叉丙二酸二乙酯 ( EMME)经缩合、环合或一步合成生成 6-氟 -7-氯 -1 ,4 -二氢 -4 -氧代喹啉

By use of MWI technology instead of the traditional two steps′ heating reaction, 6-Floro-7-Chloro-1,4-Dihydro-4-Oxoquinoline-3-Carboxlic acid ethyl ester and anologys was synthesised from 3-Chloro-4-Floro aniline and EMME condenstion in the cycle condenstion or the comdention or the one step.