摘要
目的 :观察复方中药制剂芪丹通脉片对健康犬心脏冠状动脉血流量及阻力的影响。方法 :分离犬的冠状动物左旋支及主动脉根部 ,放置电磁流量计探头 ,测定不同药物在给药前后不同时刻犬的冠状动脉血流量 ,计算冠状动脉阻力。结果 :芪丹通脉片高剂量 (生药 2 g/kg)能明显增加冠状动脉血流量 ,减少冠状动脉阻力。结论 :芪丹通脉片能够增加冠状动脉血流量 ,调整和改善心肌供血 ,为缺血性心脏病的治疗提供了实验依据。
Objective:To observe the effects of Qidan Tongmai tablet(QDTMT) on coronary blood flow and coronary resistance in healthful canine.Method:The canine circumflex branch of left coronary artery to root of aorta were separated.A probe of electromagnetic flow-meter was set in them.Coronary blood flow was measured before adminstration,and also detected at different time points after adminstration.Coronary resistance was calculated.Result:High dosage QDTMT significantly increased canine coronary blood flow(P<0.05),markedly reduced coronary resistance(P<0.05).Conclusion:QDTMT can improve coronary artery blood flow,adjust blood supply of cardiac muscle,and can be used in the prevention and treatment of ischemic cardiac disease.
出处
《安徽中医学院学报》
CAS
2001年第3期45-47,共3页
Journal of Anhui Traditional Chinese Medical College
基金
陕西省科技课题! (97K12 -G5 )
