比索洛尔治疗轻、中度原发性高血压的临床研究

Antihypertensive Effects of Bisoprolol on Hypertensive Patients

为评价比索洛尔治疗轻、中度原发性高血压的疗效和安全性 ,用比索洛尔 (5～ 1 0mg ,1 /d ,共用 8周 ,治疗轻、中度原发性高血压患者 3 0例 ,并用 2 4h动态血压监测评价用药前及 8周治疗后 2 4h血压的变化。结果 :2 9例完成治疗随访的患者中 ,降压总有效率达 86.2 % ,与用药前相比 ,治疗后的收缩压与舒张压均显著降低 ,谷 /峰比值 >5 0 % ,不良反应少 ,对血脂和血糖水平无影响。提示 ,比索洛尔降低轻、中度原发性高血压病人血压的疗效确切。

To evaluate the antihypertensive effect and safety of bisoprolol, 30 patients with mild to moderate primary hypertension were treated with bisoprolol 5 to 10 mg, once daily for 8 weeks. It were also monitored that changes of blood pressure before and after medicine by 24 h ambulatory blood pressure monitoring. 29 cases were followed up. The total effectiveness was 86.2%. Compared with pre treatment, the decreased SBP and DBP had significant statistical difference. The T/P ratio was >50%. The adverse effect was low, and there was no side effect on the metabolic of cholesterol and glucose . The results shows that bisoprolol is effective and safe in the treatment of mild to moderate primary hypertension.