IL-1B^(+3953)等位基因2多态性与中重度成人牙周炎遗传易感性的相关性分析

Study on the Relationship Between Polymorphism of IL-1B^(+3953) Allele 2 and Susceptibility of Moderate to Severe Adult Periodontitis

目的 探讨白细胞介素 - 1β(IL - 1β)基因IL -B+3953等位基因 2多态性与中重度成人牙周炎遗传易感性的关系。方法 采用病例 -对照研究方法和聚合酶链反应、限制性片段长度多态性分析 (RFLP)的方法检测 12 4例中重度成人牙周炎(AP)患者和 172例正常对照的IL - 1B+3953的基因型。结果 中重度成人牙周炎组IL - 1B+3953等位基因 2阳性基因型出现的频率为 2 8 2 3 % ,对照组为 13 95 % ,两组差异有显著性意义(χ2 =8 32 ,P =0 0 0 2 9,OR =2 42 5 ,95 %CI =1 35～ 4 34)。结论 IL - 1B+3953 等位基因 2阳性基因型可能与中重度成人牙周炎易感性有关。

Objective In order to examine the relationship between the popotymorphism of Interleukin-1β(IL-1B) +3953 allele 2 and susceptibility to moderate to severe adult periodontitis (AP).Methods A case-control study was carried out and polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP) technique was used to identify IL-1B +3953 genotype in 124 cases of moderate to severe adult periodontitis (AP) and 172 controls.Results The frequency of IL-1B +3953 allele 2 positive genotype in patients with moderate to severe AP (28.23%) showed a statistically significant increase compared to the control group frequency (13.95%) (χ\+2=8.32,P=0 0029,OR=2.425,95%CI=1.35～4.34).Conclusion IL-1B +3953 allele 2 positive genotype is relative to susceptibility of moderate to severe adult periodontitis.