矽肺患者红细胞形态参数定量研究

Study on the Ration of Morphoparameters of Red Blood Cell in Silicosis Group

方法 采用扫描电镜及MNICA36 0 0图像分析仪对 40名隧道矽肺患者进行红细胞形态参数及构成比分析。结果 与正常对照相比 ,患者红细胞平均体积增大、细胞大小分布不均 ;正常形态红细胞比例降低 ;球形、酒窝形细胞比例显著增加。肺功能失代偿者上述改变尤为显著。结论 提示形态改变是由肺代偿功能损失所致。诸多改变与矽肺引起肺功能损伤造成细胞缺氧有关。

Methods Scanning eletron microscopy and image analysis system were used to measure morphoparameters and percentage of RBC in silicosis.Results Compared with normal group,the volume of RBC in silicosis group were obviously larger and the percentage of normal form of RBC were lower;the percentage of the spherocytes and the dimplecytes in silicosis group were significantly higher.Conclusion The changes resulted from damaged breathing function.Changes were relative to RBC lacking oxygen because of the damage of lunge function caused by silicosis.