甘氨酸对热暴露大鼠的保护作用研究

Study on Protective Effect of Glycine on Heat Exposed Rats

目的 观察抗内毒素药物甘氨酸在中暑内毒素血症发病过程中所起到的作用。方法 将 2 4只受试大鼠随机分为 3组 ,每组 8只 ,两个热暴露组分别于受热前给予甘氨酸 (G)和生理盐水 (NS) ,常温对照组 (NC)暴露于室温。结果 (1)热休克发生时间 :G组 88 3± 3 5min ,NS组 79 5± 4 2min ;存活时间 (热休克发生至死亡时间 ) :G组 35 5± 4 4min ,NS组为18 0± 4 5min。组间比较有显著差异 (P <0 0 1)。 (2 )动物受试 80min后肛温、心率 ,平均动脉压分别为 :G组 42 5±0 4℃、45 9± 9 9beats/min、11 5± 0 8kPa ;NS组 43 1±0 4℃、483 3± 9 4beats/min、9 3± 0 8kPa;NC组 37 1±0 3℃、36 0 8± 10 6beats/min、13 5± 1 3kPa。不同组别对比差异显著 (P <0 0 5 )。结论 G在抗动物热暴露所致的内毒素血症中起到了相当明显的作用。

Objective To observe the effect of anti-endotoxin drug-glycine in endotoxemia led by heat stroke.Methods Twenty four rats were randomly divided into three groups,two groups with heat exposure were given glycine(G)and 0 9% saline(NS),respectively.Normal control(NC)group was exposed to room temperature.Results (1)heat shock time:G group 88 3±3 5 min,NS group 79 5±4 2min;survival time(interval between onset of heat shock and death):G group 35 5±4 4min,NS group 18 0±4 5min.There is a significant difference between each group(P<0 01).(2)the rectal temperature(Tr),heart rate,men arterial pressure after heat exposure were:G group 42 5±0 4℃、459±9 9beats/min,11 5±0 8kPa;NS group 43 1±0 4℃、483 3±9 4beats/min、9 3±0 8kPa;NC group37 1±0 3℃、360 8±10 6beats/min、13 5±1 3kPa respectively.There are significant differences among each group(P<0 05).Conclusion G plays an important role in resisting endotoxemia led by heat exposure.