肠道病毒感染的急性弛缓性麻痹病例流行病学特征分析

Epidemiological Analysis of Acute Flaccid Paralysis Cases Infected by Enterovirus

目的 分析河北省 1997～ 1999年AFP病例中肠道病毒监测结果。方法 组织培养病毒分离法。结果 河北省1997～ 1999年AFP病例中分离到的 47株脊灰病毒 ,经型内特征鉴定 ,均为疫苗病毒 ;分离到NPEV 80株 ,占AFP病例病毒分离数的 6 3% ,在明确型别的毒株中 ,有coxsackieA组 1个型别 ;coxsackieB的 5个型 ,以coxsackieB1常见 ,有ECHO的 10个型别 ,ECHO15型在 3个年度中都有分离。NPEV有明显的夏秋季高峰 ,主要发生在小年龄组人群 ;在年龄构成上以小年龄人群为主 ,5岁以下儿童的感染占 77 5 % ,2岁以内的占5 6 %。各种病毒感染均男性多于女性。有 13 3%的coxsackieB以及 2 2 2 %的ECHO感染者还在发病后 6 0天残留麻痹。结论 肠道病毒感染较普遍 ,并能引起麻痹 ,但与脊灰不易混淆。

Objective To analyse the results of virological surveillance from 1997 to 1999 of acute flaccid paralysis associated with non polio enterovirus isolation in Hebei Province.Method To use method of tissue cultivation and virus isolation.Results The evaluation demonstrated that during the period of 1997-1999 47 strains of poliovirus were isolated,they were vaccine virus;isolation of NPEV was 80 strains acounting for 63% of AFP cases.There were coxsackie A9、5 type of coxsackie B and 10 type of ECHO viruses in the isolation of NPEV.Analysis on the date,there existed peak from June to August in the NPEV infected.The group of under 5 years old was easily infected by NPEV occuping 77.5%,it was 56% under 2 years old.The male was easily infected.The 13.3% persons infected coxsakie B and 22.2% persons infected ECHO remained paralysis after being ill for 60 days.Conclusion The data indicated that,as a group,AFP cases with NPEV isolates are generally unlikely to be confused with poliomyelitis.