扩张型心肌病与免疫因素关系的研究

The Relationship between Dilated Cardiomyopathy and Immune Factors

目的：探讨扩张型心肌病（ＤＣＭ）的发病与免疫因素的关系，了解ＤＣＭ患者免疫机能状态。 方法：对８２例ＤＣＭ患者（心肌病组）进行了肿瘤坏死因子（ＴＮＦ）、可溶性白细胞介素２受体（ＳＩＬ－２Ｒ）、免疫球蛋白（Ｉｇ）及抗心肌抗体（ＡＨＡ）的测定，并以４０例健康人（正常对照组）作对照。 结果：心肌病组以上各项免疫指标均明显高于正常对照组，而且与心功能状态相关。 结论：ＤＣＭ患者免疫系统处于活跃状态，免疫系统的过度活跃可能带来了心肌细胞的变性、坏死及纤维化。

Objective: To determine the relationship of dilated cardiomyphy and immune factors, and evaluate immune condition in patients with dilated cardiomyopathy (DCM). Methods: Levels of tumor necrosis factor, soluble interleukin-2 (IL-2) receptor, immunoglobin and antimyocardial anti- body were assayed in 82 patients with DCM and 40 healthy controls. Results: The study showed that all the indexes of immunology mentioned mentioned above were higher in the patients than the controls. They were associated with the state of heart function. Conclusion: The immune system of patients with DCM is in excessively active state, thus leading to denaturation, necrosis and fibrosis.