QT离散度在冠心病中的临床应用及中药对其影响

The Clinical Application of QT Dispersion in CHD and the Influence on QT Dispersion of Chinese Herbs

综述了QT离散度 (QTd)在冠心病 (CHD)中的临床应用及中药对其影响。 1.临床应用 :在急性心肌梗死(AMI)、CHD心肌缺血 ,CHD心脏扩大和心力衰竭 (CHF) ,心律失常性猝死前QTd均较对照组增大 ,且QTd增大者更易发生恶性心律失常。临床上QTd延长常被推荐为室性心律失常 (VA)及心律失常性猝死预报因素。 2 .中药对其影响 :黄芪、参麦注射液、益气养阴、活血化瘀类中药及葛根素对QTd有单向良性影响 ,且QTd在CHD中医辨证分型中的变化规律与缩小QTd的中药属性具有相关性。结论 :鉴于西药对QTd的双向影响及致心律失常的副作用 ,提示从中药中发现高效的对QTd具有单向良性影响的中药 ,以降低VA发生率 ,提高CHD疗效。

Discuss the clinical application of QTd in CHD and the influence on QTd of Chinese herbs. ① Clinical application:QTd is longer than the control group in AMI,myocardial ischemia,cardial enlaryement,CHF,the earler stage of suddenly arrhythmical death,and the morbidity of severe arhythmia is correlated with increase of QTd.② The influence on QTd of Chinese herbs:Astragalus,shenmai injection,the Chinese herbs that benefit vital energy and yin and activate blood circulation to dissipate blood stasis,puerarin only gave good effects on QTd.Conclusions:Because of westem drugs' multiple effects and side effects that result to arrhythima,it was suggested that the Chinese herbs be found which have good influence on QTd in order to decrease the morbodity of VA and improve the therapeutic efficacy of CHD.