应激障碍患者血清细胞因子含量水平变化分析

Controlled Study on Serum Cytokine Levels in Stress-related Disorder

目的 :探讨应激障碍人体血清细胞因子的影响及相互关系。方法 :采用放射免疫测定 69例应激障碍病人及 3 1例正常人血清白介素 -2 (IL -2 )、肿瘤坏死因子 -α (TNF -α)、粒细胞 -淋巴细胞集落刺激因子 (GM -CSF)水平。结果 :应激障碍组IL -2、TNF -α、GM -CSF水平低于对照组 ,各因子间呈正相关 ,正常组无相关性。结论 :应激障碍患者的免疫功能被抑制。

Objective: To test the serum levels of cytokine in p atients with stress-related disorders, compare the result with that of normal co ntrol Method: 48 inpatients with acute stress disorder (CCMD-2 - R) and 21 inpatients with PTSD (CCMD-2-R) and 31 normal control were recruited All subjects were measured for the levels of GM-CSF, TNF-α and IL-2 with double antibodies radioimmune assay method Results: The levels of GM - CSF (030±019), TNF-α(302±066) and IL-2 (658±435) in patients wer e sign ificantly lower than the counterparts of normal control (103±110, 501±1 34 and 1083±606 respectively, p<001) There was positive correlation betwee n ea ch pair of the three indexes in patient group (r=031~054), but not in contro l group The TNF-α level was even lower in acute stress patients than that in PT SD patients (286±059/338±069, t=320, p<001) The other indexes had no diff erent between the two patient groups Similar positive correlation among each p a ir of the three indexes existed either when considering the two patient's groups separately Conclusion: Immune activation may be restrained in patients with acute or post-traumatic stress disorders