探究性眼球轨迹运动对50例精神分裂症患者及家系的分析研究

Tracking of Exploratory Eye Movement of Schizophrenics and their First Rank Relatives

目的 :探讨探究性眼球轨迹运动对精神分裂症患者的诊断及其与他们的父母、同胞等遗传关系的研究。方法 :使用眼球轨迹运动检查仪对 5 0例精神分裂症患者及其他们的父母双亲、同胞各 5 0人进行测试 ,并测试正常健康对照组 3 0人。以差别分析值 (Discriminantanalysis ,D分 )的结果来判定其是否为精神分裂症性障碍。凡D分是正分为精神分裂症性障碍 ,负分为非精神分裂症性障碍。用阳性和阴性量表(PANSS)评定精神症状 ,按ICD -10和DSM -Ⅳ诊断标准检查每一受试者。结果 :5 0例精神分裂症患者有40人D分值为正分 (40 / 5 0人 ,80 0 % ) ,患者的父亲 5 0人中有 2人确诊为精神分裂症 ,2 3人D分值为正分(2 3 / 48人 ,47 9% ) ,同胞 5 0人中有 5人确诊为精神分裂症 ,2 5人D分值为正分 (2 3 / 45人 ,5 1 1% ) ;正常健康对照组 3 0人中有 4人D分值为正分 (4/ 3 0人 ,13 3 % )。患者与父亲、母亲、同胞之间在反应性探究分(RSS)、眼运动注视点数 (NEF)、认知性探究分 (CSS)、眼视踪总距离 (TESL)、眼视踪平均距离 (MESL)等比较均有非常显著性差异 (p <0 0 1) ;在父亲与母亲、父亲与同胞、母亲与同胞之间比较除个别项目外 ,均无显著性差异 (p >0 0 5 )。结论 :眼球轨迹运动作为对精神分裂症的辅助诊断具有特异性 ,?

Objective:To track the exploratory eye movement of schizo ph renics and their first rank relativesMethod:50 schizophrenics(acco r ding to criteria of both ICD-10 and DSM-IV),their fathers(49),mothers(48),siblin gs(45)without schizophrenia and 30 control were tested by tracking of explorator y eye movementPANSS(positive and negative symptom schedule)was applied to all s ubjectsDiscriminate analysis was used to give a positive(support diagnosis of s chizophrenia)or negative score(do not support this diagnosis)Results:80% schizophrenics(40/50)got positive scoreThis rate in their fathers was 40 8%(20/49),in their mothers was 479%(23/48),in their siblings was 511%(23/45) ,i n normal control was 133%(4/30)There was significant difference of this rate b etween schizophrenics and their first rank relatives,significant difference betw een relatives and normal control,but no significant difference among first rank relativesSimilar differences were also existed in some index of exploratory ey e movement,such as RSS,NEF,CSS,TESL and MESLCoclusion:The positive s core of exploratory eye movement is specific to schizophrenia and may be a bioge netic marker of it