奥美拉唑雷尼替丁预防颅脑损伤术后应激性胃出血比较

The Contrast Study of the Prophylacxis Effects of Omeprasole and Ranitidine on Stress Bleeding of the Post operated Patients with Head Injury.

目的 :探讨奥美拉唑、雷尼替丁预防颅脑损伤手术后应激性胃出血的效果。方法 :将中、重型颅脑损伤(GCS 12～ 4分 )的手术后患者随机分为 3组 ,各 3 0例 ,奥美拉唑组、雷尼替丁组在对照组用药的基础上分别静脉滴注奥美拉唑 40mg ,qd ,和雷尼替丁 15 0mg ,bid ,观察临床出血程度。结果 :奥美拉唑组、雷尼替丁组的预防效果分别为 96 .7% ,93 .3 % ,与对照组 (76 .7% )比较差异有统计学意义 (P <0 .0 5 )。在使用额外剂量后 ,奥美拉唑组的 5例出血均停止 ,雷尼替丁组 7例出血中仍有 4例不能止血。结论 :奥美拉唑、雷尼替丁均有预防颅脑损伤手术后应激性胃出血的作用 ,且预防效果几乎相等 。

Objective:To explore the effects of prophylaxis of Omeprasole(O) and ranitidine(R) on stress bleeding following operations of head injury. Method:90cases with mild and severe head injury scoring from 12 to 4(GCS) were randomizedly divided into the contrast group(n=30) and two drug treated groups(n=30),which were treated respectively with L (40mg·d 1 ,iv.drip), R (150mg/12h,iv.drip). The clinical hemorrhage degree was observated. Results:The effects of prophylaxis on stress bleeding in L group and R group were respectively 96.7%, 93.3%.The difference between the drug treated groups with the contras group(76.7%) were significant(P<0.05). After exerting extra dose, bleeding can stop in all the 5 bleeding cases of the L group, but can't stop in 4/7 of the R group. Conclusion:Both omeprasole and ranitidine have effect of prophylaxis on stress bleeding following operations in head injury patients. Their prophylaxis effects are nearly eguivalent,but the effect of stopping bleeding of O is higher than R.