艾滋病合并肝脏肺孢子虫病一例病理观察

Pathological Changes of Diffuse Pneumocystis carinii Infection in the Liver of an AIDS Patient

目的 观察艾滋病合并播散性肺孢子虫病的肝脏改变。 方法 用 HE、PAS、吉氏、六胺银和抗酸染色观察 1例艾滋病患者肝穿刺组织病理改变。 结果 肝组织有肉芽肿形成 (抗酸阴性 ) ,血窦中见大量病原体(PAS阳性 )。吉氏、六胺银染色和电镜所见证实为肺孢子虫 (PC)感染。 结论 本例肝脏病变是肺外肺孢子虫病引起 ,为全身性播散的表现。

Objective To examine the pathological changes in the liver of an AIDS patient with complicated infection of Pneumocystis carinii(PC). \ Methods\ A liver biopsy was made. The tissue was stained with HE, PAS, Giemsa, GMS, and acid\|fast staining, and examined under light microscope and transmission electron microscope. \ Results\ Granulomas (acid\|fast negative) in the tissue and numerous pathogens (PAS positive) in hepatic sinusoids were detected. Giemsa and GMS staining and electron microscopy all confirmed that the pathogen was Pneumocystis carinii. \ Conclusion\ The pathological findings revealed a diffuse extrapulmonary infection of Pneumocystis carinii in the patient of AIDS.