2-甲基-1,3-氧硫杂环戊烷和2-丙基-1,3-氧硫杂环戊烷的合成

Synthesis of 2-Methy-1,3-oxathiolane and 2-Propyl-1,3-oxathiolane

以对甲苯磺酸为催化剂 ,巯基乙醇与乙醛、丁醛 (量比为 1.0∶1.1)在苯中共沸脱水 ,合成两种目标产物 :2 甲基 1,3 氧硫杂环戊烷、2 丙基 1,3 氧硫杂环戊烷。其产率分别为 81%和 88% ,质量分数分别为 99%和 98%。经红外光谱、色谱、质谱、核磁共振谱检测 ,确证了产物结构。此方法简便易行 。

Methy 1,3 oxathiolane and 2 propyl 1,3 oxathiolane were synthesized by the reaction of mercaptoethanol with acetaldehyde or butyraldehyde in the presence of p toluenesulfonic acid as catalyst and with benzene as azeotropic dehydrating agent.The yields were 81% and 88% and the purity were 99% and 98% respectively.Structures of the compounds were identified by the data of IR,GC-MS and 1HNMR spectra.The synthesis scheme was convenient and high yields were available.