胃食管反流病的胃排空率与感知研究

Gastric emptying and perception in gastroesophageal reflux disease

目的探讨胃食管反流病 (gastroesophageal reflux disease,GERD)患者的胃排空率，对饱胀、饥饿感知敏感性，及胃排空速度对感知的影响。方法临床诊断的 15例 GERD病人和 17例对照者采用核素法测定胃液体、固体排空功能，并记录试餐前后饱胀、饥饿计分。结果 GERD组平均胃液体和固体半排空时间显著长于对照组： GERD组在空腹时有较高的饱胀计分和较低的饥饿计分，随着胃排空延迟，餐后 GERD组饱胀计分下降和饥饿计分上升较对照组缓慢。结论 GERD病人存在胃液体、固体排空延迟；对饱胀、饥饿感知敏感性增加；胃排空速度影响对饱胀、饥饿的感知。

Objective To evaluate the gastric emptying rate and assess the perception in patients with GERD. Methods Fifteen cases of GERD and 17 controls were involved and diagnosed.The gastric emptying rates of isotope labeled liquid and solid meal were measured in both patients and controls. At the same time, the feelings of fullness and hunger were noted in marks. Results It suggested that patients exhibited a significant delay in liquid and solid gastric emptying compared with controls. Also there was a trend for the score of fullness to be higher and the score of hunger to be lower when fasting. For a period after the meal the patients still experienced fullness or discomfort and had higher fullness score or lower hunger score compared with controls.Conclusion Our data confirmed that GERD is associated with delayed gastric emptying and the increased perception. The rate of gastric emptying affects the feeling of fullness and hunger.