α-1b干扰素治疗慢性乙型肝炎疗效与血清白细胞介素-12水平的关系

The Curative Effects of α-lb Interferon Treated in Hepatitis B and the Relationship Between It and Serum IL-12

为了探讨α lb干扰素治疗慢性乙型肝炎疗效与血清白细胞介素 12水平的关系 ,应用ELISA双抗体夹心法动态检测 36例接受α lb干扰素治疗的慢性乙型肝炎患者血清IL 12的水平。治疗后血清IL 12水平显著高于治疗前 ,治疗应答组 (HBV清除和 /或HBeAg/抗Hbe血清转换 )血清IL 12水平显著高于无应答组。结论IL 12能特异性促进TH1细胞发育 ,是一种重要的抗HBV细胞因子。动态监测血清IL 12水平变化 ,是预测α

To explore the relationship between effects of interferon alfa lb (IFN α lb) treated in the patients with chronic hepatitis B and serum interleukin 12 (IL 12) level Serum IL 12 level in 36 patients with chronic hepatitis treated with interferon alfa lb (IFN α lb) was measured by enzyme linked immunosorbent assay (ELISA) method IL 12 levels after IFN α lb therapy were significantly higher than that befer IFN α lb therapy IL 12 levels in the responders groups (HBV clearance and HBeAg/anti HBe serum interchange) were significantly higher than that nonresponders groups IL 12 could enhancd the development of TH1 cells and was an important cytokines of anti HBV So it is one of a good predictor of patients with chronic hepatitis with IFN α lb by monitoring IL 12 level