瘦体重法推算内生肌酐清除率的临床应用

The clinical application of creatinine clearance predicted from lean body weight

目的 探讨瘦体重法推算肌酐清除率 (LBWCcr)在评估肾功能中的意义。方法 肾脏病人 81例分为两组 ,第 1组 5 1例用于计算 2 4h尿肌酐与瘦体重的比值 ;第 2组 30例同时测定其99mTc -DTPA清除率 (DTPA -GFR)、LBWCcr、4hCcr。以DTPA -GFR作为标准方法 ,LBWCcr、4hCcr与其进行比较 ,以验证LBWCcr检测肾小球滤过率的可行性及 4hCcr的准确性。结果 ①LBWCcr、4hCcr、DTPA -GFR三种方法进行方差分析P =0 5 6 ,无显著性差异。②LBWCcr、4hCcr与DTPA -GFR进行相关分析 ,相关系数分别为 0 89、0 86 ,显示LBWCcr与DTPA -GFR显著相关 ,且好于 4hCcr。③在肥胖组及肾功能不全组取得了相似的结果。结论 LBWCcr能准确反映肾功能 ,而且是一种简便。

Objective\ To evaluate the possibility of predicting renal function from creatinine clearance calculated by lean body weight(LBWCcr).Methods\ 81 patients of renal disease were selected.The ratio between 24-hour urinary creatinine excretion(24hUcr)and lean body weight(LBW)was evaluated in 51 patients.The other 30 patients was determined DTPA-GFR,LBWCcr and 4hCcr.DTPA-GFR was used as criteria.LBWCcr and 4hCcr were compared with it in order to validate the feasibility of LBWCcr and 4hCcr.Results\ There was no statistical significance among the three methods,P=0 56 The correlation coefficient between LBWCcr and 4hCcr with DTPA-GFR was 0 89 and 0 86,respectively.The analysis of linearity regression showed that the trend of LBWCcr was better than 4hCcrmin in predicting renal function.In fatty group and renal failure group the results were similar.Conclusion\ LBWCcr can estimate the renal function accurately,simply and rapidly.