肺源性心脏病患者胰岛功能与糖代谢异常分析

Study on function of ancreatic islets in patients with chronic pulmonary heart disease

目的 了解肺源性心脏病胰岛功能状态 ,分析肺源性心脏病糖代谢异常的原因。方法 选择无糖尿病的肺源性心脏病急性加重期患者 36例 ,进行胰岛素释放试验 ,并同健康对照组相对照。分析糖耐量及胰岛素释放曲线特征。结果 同健康对照组比较 ,肺源性心脏病患者血糖峰值为 (8 46± 0 6 1)mmol/L ,显著高于对照组 (7 5 9± 0 5 0 )mmol/L(P <0 0 1) ,峰值时间缩短 ;肺源性心脏病患者 ,胰岛素峰值为 (4 7 2± 2 1 1) μu·mL-1,显著低于对照组 (77 1± 38 2 ) μu·mL-1(P <0 0 1) ,胰岛素峰值时间延长 ,曲线平坦。结论 肺心病患者糖代谢异常 ,可能与胰岛素分泌不足和胰岛素灭活障碍有关。

Objective\ To investigate function of pancreatic islets in patients with chronic pulmonary heart disease.Method\ 36 patients with chronic pulmonary heart disease were performed insulin release test,and compared with the normal control.Results\ Blood glucose peak of chronic pulmonary heart disease was significantly higher than that of control [(8 46±0 61)mmol/L vs(7 59±0 50)mmol/L,[WTBX]P<0 01],and the peak time was short, serum insulin peak was significantly lower than that of control,and the peak time was short, serum insulin peak was significantly lower than that of control[(47 2±21 1)μu·mL -1 vs(77 1±38 2)μu·mL -1 ,[WTBX]P<0 01]..Conclusion\ There is dysfunction of pancreatic islets in patients with chronic pulmonary heart disease.