摘要
目的 :金黄色葡萄球菌 (简称金葡菌 ) ,特别是耐甲氧西林金黄色葡萄球菌(methicillin -resistantStaphylococcusaureusMRSA)是医院内感染的重要病原菌 ,并且对抗生素有较强的耐受性。本文旨在介绍MRSA的耐药性变迁情况和耐药机理。方法 :本文综述了国内外有关金葡菌耐药性的情况。结果 :自抗生素应用于临床至今金葡菌对多种抗生素产生了耐受性 ,其耐药机理 :对甲氧西林耐药主要是产生PBP2a;对氨基糖甙类抗生素耐药是由于产生了多种转移酶使抗生素活性基失活 ;对喹诺酮类药物耐受是由于靶位的改变及与菌体内物质的汲出有关。结论 :合理应用抗生素 ,对MR SA的治疗首选万古霉素 ,头孢类药物除头孢哌酮和头孢噻肟外对MRSA几乎无作用 ;丁胺卡那霉素有一定的作用。
Objective:The stapylococcus aureus,especially methicillin-resistant staphlococcus aureus(MRSA)is the important harmful bacterium in the hospital infection,and has strong resistance to antibiotics.This paper focuses on introducing the change in trend and mechanism on resistance of MRSA.Method:Integrating the information on the resistance of MRSA at home and abroad.Result:the MRSA has got the resistance since the antibiotics were applied in the clinical treatment.Mechanism:The methicillin-resistance results from producinging PBP2a;The amiaglycosides-resistance is due to its various ambulant enzyme which makes the activated-radix of antibiotics loose its active character,The quinolones-resistance is related with the target change and the drawn-out inner matter of the bacterium.Conclusion:The vancomycin is most effective in killing MRSA;The cephalosporins are hardly effective to MRSA except cefoxitin ahd ceftizoxime;Amikacin,however can do some work.
出处
《内蒙古医学杂志》
2001年第4期342-345,共4页
Inner Mongolia Medical Journal