摘要
①目的 探讨室旁核胃动素对胃运动的影响 ,了解中枢胃动素参与胃运动调节的作用和机制。②方法 应用清醒动物核团微量注射记录胃运动 ,迷走神经切断 ,辣根过氧化物酶 (HRP)逆行追踪的方法 ,观察室旁核胃动素对胃运动的影响。③结果 清醒动物微量注射胃动素入室旁核可使胃运动的幅度和频率均增大 (t =2 .2 134～ 3.0 34 4,P <0 .0 5 ) ,膈下迷走神经切断后 ,室旁核注入胃动素对胃运动幅度及频率变化的影响消失 ;HRP逆行追踪实验中 ,迷走复合体注入HRP ,动物存活 2d后可在室旁核找到HRP标记细胞。④结论 下丘脑室旁核内胃动素参与胃运动的调节 ,下丘脑 延髓迷走复合体 迷走神经
Objective To investigate the roles of motilin in PVN of hypothalamus on the regulation of gastric motility. Methods A study was conducted by means of the recordings of gastric motility in conscious rats and HRP technique. Results Gastric motility increased significantly by micro injection of motilin into PVN in conscious rats(t=2.213 4-3.034 4,P<0.05), these effects were abolished by vagotomy. In HRP trailing animals, HRP positive cells were found in PVN two days after the micro injection of HRP (0.2μL) into DVC. Conclusion All these results presented imply that motilin in PVN may take part in the regulation of gastric motility through PVN DVC Vagal nerve axis.
出处
《青岛大学医学院学报》
CAS
2001年第2期86-88,共3页
Acta Academiae Medicinae Qingdao Universitatis
基金
国家自然科学基金资助项目 ( 39970 2 80 )
