肿瘤微血管密度与肝癌临床病理及预后的关系

RELATIONSHIP BETWEEN THE INTRATUMOR MICROVESSEL DENSITY AND CLINICOPATHOLOGICAL FEATURES IN HEPATO-CELLULAR CARCINOMA

①目的 探讨肿瘤微血管密度 (MVD)与肝细胞性肝癌临床病理及预后的关系。②方法 对 30例肝细胞性肝癌根治性切除病理组织切片进行苏木精 伊红染色 ,并用CD34单克隆抗体进行免疫组化染色 ,计数被CD34抗体染色的肿瘤血管内皮细胞数 ,以测定MVD .对MVD与临床病理因素及术后生存率的关系进行分析。③结果 单因素分析结果表明 ,MVD水平与肿瘤大小、TNM分期都是影响肝细胞性肝癌预后的因素 ;多因素分析结果表明 ,肝癌大小及肿瘤分期是肝细胞性肝癌的独立预后因素。

Objective To study the relationship between intra tumor microvessel density(MVD) clinicopathological features and prognosis of patients with hapatocellular carcinoma(HCC). Methods Pathological sections of 30 cases underwent radical surgery for HCC, were evaluated after HE staining and anti CD34 monoclonal antibody immuno histochemical staining . The number of endothelia cells stained by anti CD34 antibody was counted. The relationship between MVD and survival rate after operation was evaluated. Results The survival rate was significantly lower in the tumor of larger size,poor stage and higher MVD than that in the other group(P<0.05). Conclusion MVD is one of the prognostic factors for HCC .