头孢哌酮联合罗红霉素治疗下呼吸道感染的效果观察

COMBINED USE OF CEFOPERAZONE AND FLURITHROMYCIN FOR LOWER RESPIRATORY TRACT INFECTION

①目的 评价头孢哌酮联合罗红霉素治疗下呼吸道细菌感染的临床效果及不良反应。②方法 采用随机对照研究方法 ,将 10 6例下呼吸道细菌感染病人随机分为两组 ,每组 5 3例。实验组用头孢哌酮 2 .0 g加入生理盐水 10 0mL中静脉滴注 ,罗红霉素 0 .15g口服 ,均每天 2次 ;对照组单用头孢哌酮 2 .0 g加入生理盐水 10 0mL静脉滴注 ,每天 2次。 7～ 14d为一疗程。③结果 实验组痊愈率为 6 0 .4% ,有效率为 92 .5 % ,细菌清除率为 94.4% ;对照组分别为 34 .0 % ,71.7% ,70 .4% ,两组比较 ,差异有显著性 (χ2 =7.42～ 10 .79,P <0 .0 1)。实验组不良反应发生率为 11.0 % ,对照组为 9.4% ,两组比较差异无显著性 (χ2 =0 .10 ,P >0 .0 5 )。④结论 罗红霉素与头孢哌酮联合治疗细菌感染 。

Objective To evaluate the clinical efficacy and adverse effects of cefoperazone and flurithromycin in combined therapy for lower respiratory tract bacterial infections (LRTBI). Methods 106 patients with LRTBI were randomly divided into two groups. The treat group (n=53) was treated with cefoperazone 2.0g +NS 100mL intravenous drip, twice a day, and flurithromycin 0.15g orally, twice a day. The control group (n=53) was treated with cefoperazone only , 2.0g +NS 100mL intravenous drip, twice a day. One treatment course was 7 to 14 days for both groups. Results The cure rate of treat group was 60.4% compare with 34.0% for the control group(χ2=7.42,P<0.01); the efficacy rate of treat group was 92.5% compared with 71.7% for the control (χ2=7.76,P<0.01); and the bacterial eradication rate of treat group was 94.4% compared with 70.4% for the control (χ2=10.79,P<0.005), respectively. There were significant differences between the two groups. The adverse effects of two groups was 11.0% vs 9.4% (χ2=0.10, P>0.05). Conclusion The combination of flurithromycin and cefoperazone may increase the therapeutic efficacy in the treatment of bacterial infections.