小儿慢性胃炎与幽门螺杆菌感染及治疗

The Chronic Gastritis in Children and the Infection and Treatment of Hp Department of Paediatrics

目的 探讨小儿慢性胃炎患儿血清Hp -IgG检测率及治疗方法。 方法 6 5例慢性胃炎患儿采用血清Hp -IgG检测 ,把 5 6例Hp抗体阳性患儿随机分为治疗组及对照组 ,两组皆用圣阳安中片、麦滋林—S颗粒治疗 ,治疗组加用阿莫仙胶囊和替硝唑治疗。疗程均为 2周 ,于治疗后观察临床疗效及复查血清Hp -IgG。 结果 治疗组及对照组临床总有效率分别为 96 .9%和 2 9.2 % ,Hp清除率分别为 84.4%和 12 .5 % ,两者均有显著性差异 (P <0 .0 1)。结论 说明小儿慢性胃炎与Hp感染密切相关 ,采用圣阳安中片、表滋林 -S颗粒 +阿莫仙胶囊和替硝唑四联治疗临床效果好 ,Hp清除率高 。

Objective Sixty-five children coming to our hospital for the treatment of chronic gastritis in the past two years were given the Hp-IgG test of blood serum.The results showed that fifty-six children demonstrated positive reaction (with a positivity rate of 86.2%),which indicated that the infection of Hp Could be the main causal factor of the chronic gastritis in children.Methods The fifty-six children with chronic gastritis were then randomly divided into two groups:one was the control group and the other was the experimental group.Children in the experimental group were given the treatment by having ShengYangAnZhong Tablets,Marzulene-s Granules,Amoxicillin,and Tinidazole Tablets.Children in the control group were still given the traditional treatment of the ventilation of Qi in the lung to relieve pain by having ShengYangAnZhong Tablets and Maruzulene-s Granules.Both treatments lasted two weeks.After the treatment we carried out a close study of the clinical results of therapy in both groups and gave the children a second test of Hp-IgG.Results The results showed that for the experimental group the clinical effectiveness of the treatment rated 96.9% while for the children in the control group only 29.2%.In addition,the elimination rates of Hp were 84.4% for the experimental group adn 12.5% for the control group.Both the clinical effectiveness and elimination rate of Hp show marked difference ( P <0.01),which indicated that the chronic gastritis in children had much to do with the infection of Hp.Conclusion We can say the treatment of chronic gastritis in children by giving ShengYangAnZhong Tablets,Marzulene-s Granules,Amoxicillin,and Tinidazole Tablets for two weeks is more clinically effective with a high rate of Hp elimination and a smalll aftereffects.