慢性肾小球疾病患者尿液Ⅳ型胶原的检测及意义

Significance of urine type Ⅳ collagen level in chronic glomerular disease

目的 探讨慢性肾小球疾病患者尿液Ⅳ型胶原 (Ⅳ C)的变化及其临床意义。方法 应用ELISA法测定了 5 6例慢性肾小球疾病 (CGD)患者及 1 2例正常对照 (NC)、1 0例肝硬化(NGD)患者的尿液Ⅳ C。结果 ①肾功正常的PGD患者尿液Ⅳ C高于NC ,但无统计学意义[(7.3± 6 .7) μg/Lvs(5 .7± 2 .3) μg/L ,P >0 0 5 ] ;②非肾病 (肝硬化 )患者尿液中未检出Ⅳ C ;③慢性肾功能衰竭患者尿液Ⅳ C显著高于正常对照及CGD肾功能正常患者 [(4 1 .6± 32 .9) μg/Lvs(5 .7± 2 .3) μg/L ,(1 5 .7± 1 0 .2 ) μg/L ,P <0 0 0 1 ]。 结论 ①尿液Ⅳ C为慢性肾小球疾病的较为特异的标志物 ;②尿液Ⅳ C的变化更能反映慢性肾小球疾病的发展预后。

ObjectiveInvestigate the change of urine ~{'t~} collagen(~{'t*2~}C) and clinic significance in chronic glomerular disease(CGD).MethodsELISA was used to determine the urine ~{'t*2~}C of 56 c ases with CGD and 12 cases normal control(NC).ResultsUrine ~{'t*2~}C level of CGD with normal renal function w as higher than that of NC, but there was no significant difference[(7.3~{!@~}6.7)~{&L~} gL~{*,*)~}-1 ~{**~} vs(5.7~{!@~}2.3)~{&L~}gL~{*,*)~}-1~{**~},~{*+~}P~{*+~}>0.05];~{'Z~}It couldn't be detected in the ur ine of nonglomer ular disease;~{'['t*2~}C of chronic renal failure was significantly higher than that of CGD with normal renal function and NC[(41.6~{!@~}32.9)~{&L~}gL~{*,*)~}-1~{**~} vs(5.7~{!@~}2. 3)~{&L~}gL~{*,*)~}-1~{**~},(15.7~{!@~}10.2)~{&L~}gL~{*,*)~}-1~{**~},~{*+~}P~{*+~}<0.001].ConclusionUrine ~{'t*2~}C was a specific marker in CGD;~{'Z~}Urine ~{'t*2~}C can well reflect the prognosis in CGD.