用晨尿代表尿汞水平的可行性研究

The Feasibility by Using Morning Urine Samples to Represent Urinary Mercuric Contents

目的 探讨尿汞检测采用一次性尿样的可行性 ,解决实际工作中的收集全日尿的烦琐、污染、酸败等问题。方法 采用冷原子吸收法 -碱性氯化亚锡还原法 ,对正常人的晨尿和全日尿汞含量进行比较。结果 晨尿与全日尿汞含量经配对t检验 ,二者差异无显著性 (P >0 .0 5 ) ,相关分析r =0 .6 6 71 ,相关非常显著 (P <0 .0 1 ) ;尿比重校正法校正及尿肌酐校正法校正的晨尿与全日尿汞含量比较、二者均存在显著性差异 (P <0 .0 1 )。结论 用晨尿所检测的尿汞结果可代替全日尿汞含量用来评价汞接触水平。

Objective To discuss the reliability of determination of urinary mercuric contents by the use of single collected urinary sample and to solve the problems of troublesome, contamination, acid putrity occurred in the collection of 24 h urine samples. Method Alkaline chlorous tin -spectrophotometry (cold atomic absorption) was adopted to determine and compare the mercuric contents in morning urine and 24 h urine samples in healthy persons. Results The difference between mercuric contents of morning urine and those of 24 h urine compared by matched pair t test was not significant(P>0.05). On the contrary, through correlative analysis they correlated significantly, r=0.6671.Mercuric contents between morning urine after standardization by specific gravity or by the contents of creatinine were significantly different from mercuric contents of 24 h urine(P<0.01). Conclusions Morning urinary mercuric contents can replace the 24 h urinary mercuric contents and can be used to estimate the mercuric exposure level. The determination of urinary mercury was not influenced by urinary concentration.