循证医学对肿瘤临床实践的影响

Influence of Evidence-based Medicine on Clinical Practice of Oncology

循证医学正在越来越深刻地影响着肿瘤学的临床实践 ,临床随机对照研究和在这一基础上建立起来的系统分析 ,把一些理论上认为应该有效或经验认为有效的治疗方法 ,证实在实际上是无效或害大于利 ,而另一些被认为似乎无效的治疗方法却被证实利大于害 ,应该推广。本文着重探讨了疗效判断中终点指标和中间指标的不同 ,探讨了系统评估对肿瘤临床实践的影响。

Evidence-based medicine is influencing clinical oncology. Clinical randomized controlled trials (RCT) and systematic reviews based on RCT confirmed some methods that were regarded as effective in theorectical or experience as ineffective or even more harmful than benefit in practice.Some methods regarded as ineffective were confirmed as benefit over harmful. In this paper some differences between inter and end point index were discussed.The influence of systematic review on clinical practice of oncology was evaluated.