血清鳞状细胞癌抗原在宫颈鳞状细胞癌中的变化及意义

Significance of Squamous Cell Carcinoma Antigen in Squamous Cell Carcinoma of the Uterine Cervix

[目的]探讨血清鳞状细胞癌抗原水平在宫颈鳞状细胞癌中的变化及其临床意义。[方法]应用微粒子酶免分析(MEIA)对2000年3月～2000年7月在浙江省肿瘤医院收治的宫颈鳞癌 (包括5例鳞腺癌 )165例患者进行血清鳞状细胞癌抗原水平检测并分析其与临床分期、肿瘤大小、病理分级、淋巴结转移之间关系 ,其中放射治疗的93例患者进行治疗前后的血清鳞状细胞癌抗原水平的自身比较 ,以及与近期疗效的关系。[结果]165例宫颈鳞癌患者血清鳞状细胞癌抗原阳性率为64.2% (106/165)。鳞状细胞癌抗原水平与临床分期、肿瘤大小有关 (P<0.05) ;与病理分级、淋巴结转移之间无统计学差异 (P>0.05) ;放射治疗前后患者血清鳞状细胞癌抗原水平变化有统计学意义 (P<0.05 ) ,且与疗效相关 (P<0.05)。[结论]血清鳞状细胞癌抗原是宫颈鳞癌的相关的肿瘤标记物 ,在监测宫颈鳞癌的发生和评价疗效等方面具有重要价值 。

To investigate the significance of serum squamous cell carcinoma antigen in squamous cell carcinoma of the uterine cervix. The relationship between the level of squamous cell carcinoma antigen and the clinical features of 165 patients with squamous cell carcinoma of the uterine cervix ( including 5 patients with squamous adenocarcinoma) were evaluated.The preradiotherapy and postradiotherapy level of squamous cell carcinoma antigen(SCCag) were compared. The positive rate of squamous cell carcinoma antigen in the 165 patients with squamous cell carcinoma of the uterine cervix in serum was 64.2% (106/165). The level of SCCag related with the clinic stage and the size of lesion (P<0.05). The level of SCCag was not statistically different among pathological grades and between patients with lymph node metastasis and without node metastasis (P>0.05).The postradiotherapy serum level of SCCag decreased significantly compared to that before the radiotherapy (P<0.05 ). The level of SCCag related to therapeutic effect significantly (P<0.05 ). [Conclusion] SCCag is an important marker related to the squamous cell carcinoma of the uterine cervix and the clinical response . It plays clinical role for estimating prognosis.