短暂性全面遗忘症的认知功能和MRI及PET的对比研究

Contrast study on cognitive function with MRI and PET imaging in TGA

目的 研究短暂性全面遗忘症 (transientglobalamnesia ,TGA)患者认知功能及脑代谢状况。方法 对 3例临床诊断为TGA的患者分别行简易心理测试 (MMSE)、修订的韦氏记忆量表 (WMS R)测定和脑核磁共振成像 (MRI)检查 ,在恢复后不同时间以18氟标记的脱氧葡萄糖 (18F FDG)为示踪剂行脑正电子发射型计算机断层扫描 (positrone missiontomography ,PET)成像 ,并对其图像、量表测试结果与病史作对照研究。结果 3例患者MMSE测试及MRI扫描均未见明显异常 ,而WMS R测试及PET成像显示 :1例正常 ,另外 2例有不同程度认知功能损害 ,与记忆相关结构有不同程度的低代谢。结论 TGA患者认知功能及局部脑代谢与其症状持续时间密切相关 ,尽早终止其发作是必要的。

Objective To study the cognitive function and cerebral metabolic changes in the patients with transient global amnesia(TGA).Methods Three patients with TGA were given mini mental state examination (MMSE),revised Wechsler memory scale (WMS R) examination and MRI scan when they had been diagnosed as TGA.Using 18 F labelled deoxy glucose as tracer,the patients were given positron emission tomography (PET) examination at the different periods after recovery.Results No obvious abnormality was found in MMSE and MRI scan of the three patients.However,WMS R examination and cerebral PET imaging displayed cognitive dysfunction in various degrees and low metabolism in local areas related with memory in 2 of 3 patients.Conclusions In TGA patients,the cognitive function and cerebral metabolic levels are closely correlated with duration of symptoms.It is necessary to prevent the TGA attack in early time.