p16蛋白在食管鳞癌中的表达及其意义

Expression of p16 Protein in Human Esophageal Squamous Cell Carcinoma

目的 :研究 p16蛋白表达与食管鳞癌生物学行为的关系。方法 :应用免疫组化LSAB法检测52例食管鳞癌p16蛋白表达。结果 :21例食管鳞癌 p16蛋白表达阳性 ,阳性率为40.4 %。随着恶性程度增加及病程进展 ,p16蛋白阳性率逐渐下降 ;p16蛋白阳性与淋巴结转移有关。p16蛋白阴性患者死亡率明显高于 p16蛋白阳性者 ,且存活时间短。结论 :检测食管鳞癌组织 p16蛋白表达 ,有助于综合判断食管鳞癌恶性程度、转移潜能和预后。

Objective:To study the relationship between the expression of p16 protein and the biologic behavior of human esophageal squamous cell carcinoma.Methods:By using immuno-histochemical LSAB technique,p16 protein was examined in 52 cases of esophageal squamous cell carcinoma.Results:The expression of p16 protein was found positive in 21 cases among 53 cases (positive rate 40.4%).It was found that the increasing of malignancy and the progressing of the disease were accompanied with the gradual declining of the positive rate of p16 protein expression.We also found that the higher the positive rate of p16 protein expression,the lower would be the lymph node metastatic rate;and the higher the positive p16 protein expression rate,the higher the survival rate and the longer survival time.Conclusion:Our results demonstrated that the examination of p16 protein expression in human esophageal squamous cell carcinoma may be have significant prognositic value for assessing the degree of malignancy;potential lymph node metastatic probability and survival probability of this disease.