唾液酸化路易斯-X抗原在人宫颈癌组织的表达及其临床意义

The expression of sialyl Lewis-X antigen in human cervical carcinoma tissues and its clinical significance.

目的 :探讨唾液酸化路易斯 -X抗原 (SLeX)在人宫颈癌组织的表达及其意义。方法 :采用免疫组化染色技术检测 10 0份宫颈癌组织 ,30份不典型增生组织及 10份正常宫颈组织中SLeX 表达 ,应用图像分析系统定量分析其表达水平。结果 :SLeX 在非癌组织中无表达 ,在宫颈癌组织中的表达率为 6 9% ,其表达与宫颈癌的病理类型、癌灶大小和患者年龄无关 (P >0 .0 5 ) ;SLeX 在细胞分化程度低、临床分期晚、有转移、复发及预后差的患者中表达显著增高 (P <0 .0 1或P <0 .0 5 )。结论 :SLeX

Objective:To discuss the expression of sialyl Lewis-X antigen (SLe X) in human cervical carcinoma tissues and its clinical significance.Methods:The expression of SLe X in 100 samples of cervical cancer tissues,30 samples of atypical hyperplasia and 10 samples of normal cervical tissues were detected by means of immunohistochemical stain and image analysis system for quality and quantity tests.Results:The expression of SLe X in non-carcinoma tissues could not be detected,the expression rate in cervical cancer tissues was 69% and the expression was not related with the cervical cancer pathologic types,cancerous focus sizes and patients' ages (P>0.05 respectively).SLe X was high significantly in the patients with poor cell differentiation,advanced stages,metastasis,recurrent and poor prognosis(P<0.01 or P<0.05). Conclusions:The expression of SLe X can be used as the new marker for reflecting the cervical malignancy potential and patients' prognosis.