CD_(44)V_6表达与乳腺癌临床病理因素及预后的关系

Expression of CD_(44)V_6 in invasive breast carcinoma and its relationship with prognostic significance

目的 探讨乳腺癌组织中CD4 4V6表达与临床病理因素及预后的关系。方法 对经治疗后随访 8年以上的乳腺癌病人 5 6例 ,应用S P免疫组化法 ,检测癌组织中CD4 4V6表达 ,将其结果与影响预后的临床病理因素及生存状况进行比较。结果 CD4 4V6在癌组织中的表达率为 80 .4% ,淋巴结阳性及组织学分级高的病例 ,CD4 4V6阳性表达明显增加 ,死亡组CD4 4V6阳性表达明显高于存活组。结论 CD4 4V6的阳性表达与乳腺癌的恶性程度和不良预后有关。CD4 4V6可做为估计乳腺癌预后和指导临床治疗有价值的参考指标。

Objective To evaluate the relationship between CD_ 44V_6 and the prognosis in invasive breast carcinoma.Methods Comparison was made between 31 paitents with axillary node negative carcinoma and 25 patients with axillary node positive carcinoma for a minimum follow-up of 8 years.The level of CD_ 44V_6 (56 cases) expression was observed and compared with clinical and pathologic factors affecting prognosis and survival.Results Positive rate of CD_ 44V_6 expression was 80.4%.CD_ 44V_6 expression increased in node positive and high histologic grade patients.Conclusion Up regulation of CD_ 44V_6 expression correlates with malignancy of breast cancer.CD_ 44V_6 expression may serve as an important indicator of prognosis and guidance for clinical treatment.