NVB治疗晚期恶性肿瘤临床研究

Clinical efficacy of navelbine in treating advanced tumor

目的 观察以异长春花碱 (NVB)为主的联合化疗方案治疗晚期恶性肿瘤的疗效。方法 共收治 30例晚期恶性肿瘤接受以NVB为主的联合化疗 ,其中非小细胞肺癌 13例 (4 3.3% ) ,乳腺癌 6例 (2 0 % ) ,鼻咽癌 4例 (13.3% ) ,恶性淋巴瘤 4例 (13.3% ) ,食道癌 3例 (10 % )。非小细胞肺癌、鼻咽癌、食道癌的化疗方案为NP ,乳腺癌为NA ,恶性淋巴瘤为CHNP。结果 30例患者可评价疗效和毒性。其中CR1例 ,PR14例 ,总有效率为 5 0 %。血红蛋白减少发生率为 37% ,白细胞为 76 .6 % ,血小板为 33.3% ,恶心呕吐发生率为 70 % ,便秘为 5 6 .6 % ,腹痛为 16 .6 % ,神经毒性为 13.3% ,静脉炎为30 % ,脱发为 33.4% ,皮疹为 6 .6 % ,发热为 10 % ,口腔黏膜溃疡为 10 % ,肝功损害为 13.3% ,肾功损害为 6 .6 %。结论 本组观察提示 ,异长春花碱联合治疗非小细胞肺癌、乳腺癌、鼻咽癌、恶性淋巴瘤、食道癌等晚期肿瘤有较好疗效 ,且毒性可耐受 ,对晚期肿瘤患者是个很有前途的肿瘤内科治疗药物。

Objective To evaluate the effect of chemotherapy mainly contained navelbine in treating advanced tumors.Methods 30 patients with advanced tumor were treated by combined chemotherapy of NVB,among whom 13 patients(accounting for 43.3%)were with NSCLC,6(20%) with breast cancer,4(13.3%)with nasopharyngeal cancer,4(13.3%) patients with NHL,3(10%) with esophageal cancer.NP regimen was applied to NSCLC?nasopharyngeal cancer and esophageal cancer,NA to the breast cancer and CHNP to the NHL respectively.Results The effectiveness as well as tolerable toxicity was estimated in total 30 cases.The general effective rate was about 50%,with CR accounting for 1 case and PR for 14 cases.And decrease of HGB?WBC and PLT occurred in a rate of 37%?76.6% and 33.3% respectively,side effect mostly including nausea, vomiting, constipation,bellyache, nerve toxicity,phlebitis,alopecia, skin rash, fever,oral sore of mucous membrane,damage of liver and kidney function.Conclusion A better response rate is obtained by combination chemotherapy with NVB for treating the advanced tumor,including NSCLC?breast cancer?nasopharyngeal cancer(carcinoma)?NHL and esophageal cancer.NVB is a promising antitumor agent with tolerable toxicity.