充血性心力衰竭QT离散度变化及美托洛尔对其影响

QT interval dispersion in congestive heart failure and the effect of metoprolol on QTd

目的 :测定充血性心力衰竭 (CHF)患者的 QT离散度 (QTd)及美托洛尔对 QTd的影响。方法 :110例 CHF患者和 5 0例健康人同时作 QTd测量 ,CHF患者中 38例进行美托洛尔治疗 ,与未使用美托洛尔的 78例作比较。结果 :CHF患者的 QTd明显高于健康人 (P<0 .0 1) ;QTd与心功能受损的程度呈正相关 ;CHF伴室性心律失常者QTd大于不伴室性心律失常者 (P<0 .0 5 ) ;予美托洛尔治疗后 CHF患者 QTd明显缩短 (P<0 .0 5 )。结论 :CHF患者 QTd明显增大。美托洛尔可使 QTd缩小 。

AIM:To detect the changes of QT interval dispersion(QTd) in congestive heart failure (CHF) and the effects of metoprolol on QTd. METHODS:The QTd was measured in 110 patients with CHF and 50 healthy peoples. 38 patients with CHF were recruited at random from 110 cases and treated by metoprolol,78 cases serving as controls. The QTd was measured before and four weeks after the treatment . RESULTS:The QTd in CHF was significantly prolonged as compared with that of healthy people( P <0.01). The QTd was positively correlated with the NYHA class of cardiac function. The QTd in CHF patients with ventricular arrhythmias obviously increased as compared with that in CHF patients without ventricular arrhythmias ( P <0.05). In the ptients treated with metoprolol,QTd significantly reduced ( P <0.05). CONCLUSION:The QTd was prolonged in CHF. The QTd in CHF with ventricular arrhythmia obviously increased. Metoprolol could diminish the QTd in CHF,which is beneficial to the prevention of malignant ventricular arrhythmia and sudden death.