萘哌地尔的药理学研究和临床应用

The pharmacology and clinical uses of naftopidil

萘哌地尔是一种新型的选择性α1 受体阻断剂 ,其α1 受体阻断作用具有组织选择性和受体亚型的选择性 ,并且可阻断钙通道、兴奋 5 HT1A受体。在临床上主要用于治疗高血压病和良性前列腺增生。本文就萘哌地尔的药代动力学、药效学。

Naftopidil is a new type of selective α 1 adrenoceptor antagonist.It possesses the selectivity of tissue and subtype α 1 adrenoceptor,exhibits calcium channel blocking effect and excits 5 HT 1A receptor.In clinical setting,it is mainly used to treat essential hypertension and benign prostate hyperplasia.In this paper,the pharmacodynamics,pharmacokinetics,initial clinical trials,and safety of naftopidil were reviewed.