地塞米松对创伤性休克时外周血一氧化氮和内皮素-1的影响

The new mechanism of dexamethasone on treating traumatic shock

目的 :了解地塞米松对创伤性休克时外周血一氧化氮和内皮素 -1的影响。方法 :复制兔创伤性休克模型 ,测定创伤前、后外周血内皮素 -1和一氧化氮浓度变化并观察地塞米松对内皮素 -1和一氧化氮浓度的影响。结果 :创伤性休克时 ,对照组内皮素 -1和一氧化氮浓度显著升高 (P <0 .0 1 ) ;治疗组内皮素 -1浓度升高更加显著 (P <0 .0 1 ) ,而一氧化氮浓度则明显降低 (P <0 .0 1 )。治疗组动物存活时间显著延长 (P <0 .0 1 )。结论 :内皮素 -1和一氧化氮参与了创伤性休克的病理损伤过程 ;地塞米松通过影响内皮素 -1和一氧化氮的浓度变化来发挥其对休克的治疗作用。

Objective:To observe the alteration of endothelin-1 and nitric oxide treating by dexamethasone on traumatic shock.Methods:By reconstructing a rabbit traumatic shock model,the changes of endothelin-1 and nitric oxide concentration in peripherial blood pre-and-post trauma were measured.Results:The concentration of endothelin-1 and nitric oxide in control group increased significantly.While in the treatment group,the concentration of endothelin-1 increased much higher than that in control group and the concentration of nitric oxide decreased.The survival time of treatment group was longer than that of control group.Conclusion:The results demonstrated that endothelin-1 and nitric oxide play a role in traumatic shock and dexamethasone has treatment effects on traumatic shock by altering the concentration of endothelin-1 and nitric oxide in peripherial blood.