卡维地洛治疗充血性心力衰竭疗效观察

The clinical efficacy of carvedilol for treatment of congestive heart failure

目的 :通过对各种病因的充血性心力衰竭 (CHF)患者应用卡维地洛治疗 12个月 ,以了解其能否提高CHF的有效率和生存率。方法 :96例CHF随机分成两组 ,在接受常规利尿、洋地黄、血管紧张素转换酶抑制剂 (ACEI)等治疗的基础上 ,分别给予安慰剂 (对照组 )和给予终点剂量卡维地洛治疗 40mg/d ,从小剂量开始 ,逐渐增加剂量 ,观察 12个月 ,计算出总有效率和总病死率。结果 :卡维地洛组的总病死率比安慰剂组下降了 6 0 % (P <0 0 0 1) ,总有效率比安慰剂组提高了 5 0 % (P <0 0 5 )。结论 :应用卡维地洛治疗CHF ,可明显提高总有效率 ,降低病死率 。

Objective:To apply carvedilol on the patients suffering from congestive heart failure resulting from all kinds of pathogenies for twelve months to see whether or not the efficacy rate of CHF and the survival rate can be increased.Methods:Divide at random the cases of CHF into two groups.On the base of conventional treatment of diuresis,digitalis,augiotensin-converting enzyme inhibitor give one group (contrast group) placebo,the other group the endpoint dosage of carvedilol 40 mg/d.Take small dose at initial stage,then step by step,increase the dosage,after twelve months of observation,count the total rates of efficacy and mortality.Results:In carvedilol group mortality rate decreases by 60% (P<0 001),while the efficacy rate increases by 50% (P<0 05) compared with those in placebo group.Conclusion:Carvedilol for treatment of CHF can apparently increases the total efficacy rate,longterm survival rate,decreases mortality rate.\;