摘要
目的:探讨ＭｇＳＯ４对大鼠脑缺血再灌流损伤的保护作用。方法:线栓法将ＳＤ大鼠制成脑缺血再灌流模型,分组测定脑组织Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ活性、ＭＤＡ、ＮＯ含量。结果:治疗１组(３００ｍｇ·ｋｇ－１)和治疗２组(６００ｍｇ·ｋｇ－１)与对照组比较,Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ活性增加,ＭＤＡ、ＮＯ含量降低,且治疗２组比治疗１组作用更明显。结论:ＭｇＳＯ４对脑缺血再灌流损伤有保护作用,６００ｍｇ·ｋｇ－１较３００ｍｇ·ｋｇ－１更显著。
Aim: To evaluate therapeutic effects of magnesium sulfate (MgSC4) after cerebral ischemic reperfusion. Methods: Using the Sprague-Dwaley(SD) rat model of cerebral ischemia and reperfusion (middle cerebral artery occlusion,MCAO), we observed the Na+-K+-ATPase activity changes, malonicaldehyde(MDA) and nitricoxide (NO) levels. Results:Compared with the control groups,cerebral Na+-K+-ATPase activity in the treatment group increased, MDA and NO decreased significantly, the changes were more significant in treatment No. 2 group than in treatment No. 1 group. Conclusion:MgS04 has an obvious protective effect when administered after cerebral ischemia and reperfusion, furthermore, the larger dose of MgS04 administration has much better protective effects than the smaller dose.
出处
《中国临床神经科学》
2001年第3期246-248,共3页
Chinese Journal of Clinical Neurosciences
