心脉龙对两种实验性心脏疾病模型的治疗作用

Therapeutic Effects of Complex Nucleosides from Chinese Medicine on Two Experimental Models of Heart Failure

在麻醉犬结扎冠状动脉左前降支造成心梗以及麻醉大鼠静注心得安和戊脉安混合液所致急性心衰的两种模型上,心脉龙均显示增强心肌收缩力并增加心输出量,对外周阻力、心肌耗氧量和心率等无明显影响。对缺血所致 ST 段抬高也未见明显作用。在戊脉安和心得安所致大鼠心衰模型上,多巴胺2mg/kg iv 的心血管效应与心脉龙相似。

Therapeutic effects of complex nucleosides were studied by using two models of heart failure caused by either the ligation of the anterior interventricular branch of the coronary ar- tery in anesthetized dogs or iv injection of a mixed solution of verapamil and propranolol (0.5mg/Kg respectively)in anesthetized rats.After iv complex uncleosides 0.5mg/Kg/min for 10 min in the dogs and 5 mg/Kg/min for 4 min in the rats,a positive inotropic effect and an increase of cardiac output were observed,but no influence on the peripheral resistance,myocardial oxygen consumption and heart rate.Complex nucleosides had no effect on the S-T segment elevation due to the myocardial ischemic injury.On a rat model of verapamil and propranolol-induced heart failure dopamine 2 mg/Kg iv showed cardiovascular effects,which is similar to complex nucleosides.