丙硫咪唑对异盘并殖吸虫皮层及肠上皮作用的扫描电镜观察

Scanning Electron Microscopical Observations on Damages to Tegument and Gut Epithelium of Paragonimus Heterotremus by Albendazole

将丙硫咪唑按100mg/kg/d×2灌胃治疗大鼠异盘并殖吸虫病。扫描电镜显示虫体皮层明显水肿,尾部塌陷。治疗后第5天口吸盘周围皮层水肿呈棉絮状,腹吸盘周围皮层灶性坏死,尾部尚见肿胀之乳突,肠上皮灶性坏死,片层融合成板状。

The adult worms of Paragonimus heterotremus obtained from experimental infected rats were observed under a scanning electron microscope.24 hours after gastrogavage of albendazole 100mg/kg/d×2,the whole tegument of the worms was markedly swelled,and the posterior togument showed hollow.After 5 days the swollen tegument around the oral sucker looked like cotton fibre,the tegument around the ventral sucker showed local necrosis, and the posterior tegument still showed swollen papillae.The gut epithelium showed local necrosis and the lamella on its surface formed lumps.