对小鼠急性乏氧性缺氧时耗氧量等指标的动态观测

Dynamic Observations on Mouse Oxygen Consumption and Some Other Indices during Acute Hypoxic Hypoxia

本文报道了病生缺氧实验中耗氧量测定方法的改进,让学生观察到小鼠急性进行性乏氧性缺氧全过程中耗氧率和呼吸频率的动态变化规律。实验结果还表现:耗氧率和呼吸频率达最高值的时问随存活时间延长,并且后者更明显。在容积相同的闭路装置中,动物体重愈大,存活时间愈短,但是个体间的差异大。

In this article,the authors reported a modified method of determining Oxygen consump- tion for the mouse hypoxia experiment in order that the students could observe the dynamic change of oxygen consumption rate(OCR)and respiratory rate(RR)in the whole process of acute progressive hypoxic hypoxia on mice.The results showed that to reach the maximal OCR and RR,especially the latter,required more time as the survival time was prolonged. In a closed set of the same size,the heavier the mouse weighed,the shorter it survived,but there was an individual difference.