摘要
用半经验的 MNDO 法对几个模拟丝氨酸蛋白酶活性中心的系统作了研究,发现稳定化能与攻击基团的亲核能力密切相关。活化能的减少估计为9千卡/摩。表明氨键的形成并不能改变底物的形变。
Using the semiempirical MNDO method,several systems simulating the active site of serine proteases have been studied.The stabilization energy was found depending strongly on the nucleophilicity of the attacking group.the decrease of the activation energy has been esti- mated at 9 kca/mole.It was shown that the substrate distortion did not vary with the form- ing of hydrogen bonds.
出处
《昆明医学院学报》
1991年第4期36-38,共3页
Journal of Kunming Medical College