间歇大剂量马利兰治疗慢性粒细胞白血病远期疗效观察

Long-Term Effects of Intermittent High-Dose Myleran on Chronic Granulocytic Leukemia

本文报道36例慢性粒细胞白血病(慢粒)患者,经间歇大剂量马利兰治疗后,与31例常规疗法相比较,近期疗效优于常规疗法组。但远期疗效观察,急变发生率为61%,急变发生时间平均在确诊后34.7个月,中位生存期31.25个月,与常规小剂量连续给药组相比较,无显著性差异。

36 Patients of chronic granulocytic leukemia were treated with intermittent high-dose myleran.It was shown that the short-term effect was better than that of the conventional lower dose method.Remission occurred earlier and severe suppression of bone marrow was rare.This method was simple and feasible.However,the incidenee of blast crisis was 61%.Its average occurring time was 34.7 months after being diagnosed,and the middle survivai peri- od was 31.25 months.There is no significant difference as compared with the control.