摘要
为观察小鼠和大鼠灌服小儿康冲剂所产生的毒性反应 ,以确定临床用药的安全性 ,按《中药新药研究指南》的毒性试验要求对其进行了研究 .结果表明 :小儿康冲剂急性毒性实验以灌胃和腹腔注射给药的半数致死量 (LD50 )分别为 2 0 .4 9g·kg- 1和 9.78g·kg- 1;大鼠长期毒性实验灌胃给药分别为 12g·kg- 1、6g·kg- 1和 3g·kg- 1,连续 6周 ,各组动物无死亡 ,动物一般症状、体重增长、血液学、血液生化学、各脏器指数与对照组比较无显著差异 ,脏器病理组织检查试验期和恢复期未见明显病变 .
According to the requirement of Research Guideline of New Chinese Medicines ,the toxic tests of Xiaoerkang Granule(XEKG) were studied.The results showed that in the mice's acute toxicity test to Xiaoerkang granule,the LD 50 respectively were 20.49 g·kg -1 and 9.78 g·kg -1 by intragastric feeding and intraperitoneal injection,and in the long term toxicity test to XEKG,when the dosages of 12 g·kg -1 ,6 g·kg -1 ,3 g·kg -1 were respectively administrated to rats by intragastric feeding and continued to the sixth week,no dead animal was observed,and these aspects,such as animal's symptom,increase of body weight,hematology,hematology biochemics and organ indexes had not significant difference with control group.By histopathological examination,the pathologic change of organ didn't obviously appear during test period and restoration stage.All these indicated that the toxic effect of XEKG was low by oral administration in clinical practice.
出处
《海南大学学报(自然科学版)》
CAS
2001年第3期265-268,共4页
Natural Science Journal of Hainan University